Donoghue Lab

updated February 4, 2008

Neural Prostheses/Brain Machine Interface
Neural Representation/Coding Motor Control
Motor Plasticity

Neural Prostheses/Brain Machine Interface

Truccolo, W., Friehs, G.M., Donoghue, J.P., Hochberg, L.R. (2008).
Primary Motor Cortex Tuning to Intended Movement Kinematics in Humans with Tetraplegia.
Journal of Neuroscience January 30, 2008, 28(5):1163-1178.
PDF
supplemental text

Nalatore, H., Truccolo, W., Rangarajan, G. (2008)
Fast Robust Pattern Classification Algorithms for Real Time Neuro-Motor Prosthetic Applications.
Journal of the Indian Institute of Science, (in press).

Truccolo, W. & Donoghue, J.P., (2007)
Nonparametric Modeling of Neural Point Processes via Stochastic Gradient Boosting Regression.
Neural Computation, 19(3), 672-705.
PMID: 17298229 [PubMed - indexed for MEDLINE]
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Kim, S-P, Simeral JD, Hochberg LR, Donoghue JP, Friehs Gm, and Black MJ (2007)
Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia
Neural Engineering, 2007. CNE '07. 3rd International IEEE/EMBS Conference, 2-5 May 2007 Pages:486 - 489
Digital Object Identifier 10.1109/CNE.2007.369715
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Artemiadis, P., Shakhnarovich, G., Vargas-Irwin, C., Black, M. J., Donoghue, J. P. (2007)
Decoding grasp aperture from motor-cortical population activity,
Neural Engineering, 2007. CNE '07. 3rd International IEEE/EMBS Conference, 2-5 May 2007 Pages:518-521.
PDF

Vargas-Irwin C, Donoghue JP (2007)
Automated spike sorting using density grid contour clustering and subtractive waveform decomposition.
J Neurosci Methods. 2007 Aug 15;164(1):1-18.
Epub 2007 Apr 12.
PMID: 17512603 [PubMed - in process]
doi:10.1016/jneumeth.2007.03.025

Donoghue JP, Hochberg LR, Nurmikko AV, Black MJ, Simeral JD, Friehs G (2007)
Neuromotor prosthesis development.
Med Health R I. 2007 Jan;90(1):12-5.
PMID: 17487029 [PubMed - indexed for MEDLINE]
http://www.health.ri.gov/publications/medhealthri/RIMed_Jan07CME.pdf

John P. Donoghue, Arto Nurmikko, Michael Black, and Leigh R. Hochberg (2007)
Assistive technology and robotic control using motor cortex ensemble-based neural interface systems in humans with tetraplegia.
J Physiol. 2007 Mar 15;579(Pt 3):603-11.
Epub 2007 Feb 1. Review.
PMID: 17272345 [PubMed - indexed for MEDLINE]
DOI: 10.1113/jphysiol.2006.127209
http://jp.physoc.org/cgi/content/full/579/3/603

Ojakangas CL, Shaikhouni A, Friehs GM, Caplan AH, Serruya MD, Saleh M, Morris DS, Donoghue JP (2006)
Decoding movement intent from human premotor cortex neurons for neural prosthetic applications.
J Clin Neurophysiol. 2006 Dec;23(6):577-84.
PMID: 17143147 [PubMed - indexed for MEDLINE]

Hochberg LR, Donoghue JP (2006)
Sensors for brain-computer interfaces.
IEEE Eng Med Biol Mag. 2006 Sep-Oct;25(5):32-8. Review.
PMID: 17020197 [PubMed - indexed for MEDLINE]
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Wood, F., Goldwater, S., and Black, M. J. (2006)
A non-parametric Bayesian approach to spike sorting
International Conference of the IEEE Engineering in Medicine and Biology Society, New York, NY, Aug-Sep, pp. 1165-1169, 2006.
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Friehs, Gerhard M.D.; Penn, Richard D. M.D.; Park, Michael C. M.D., Ph.D.; Goldman, Marc M.D.; Zerris, Vasilios A. M.D.; Hochberg, Leigh R. M.D., Ph.D.; Chen, David M.D.; Mukand, Jon M.D., Ph.D.; Donoghue, John D. Ph.D. (2006)
Initial Surgical Experience with an Intracortical Microelectrode Array for Brain-computer Interface Applications: 881. [Abstract]
Neurosurgery 59(2):481, August 2006.

Aaron, R.K., Herr, H.M., Ciombor, D.McK., Hochberg, L.R., Donoghue, J.P., Briant, C.L., Morgan, J.R., and Ehrlich, M.G. (2006)
Horizons in prosthesis development for restoration of limb function.
J. Am. Accad. Ortho. Surg. 2006, 14(10), S198-204S

Abstract:
http://www.jaaos.org/cgi/content/abstract/14/10/S198?ct=ct

Hochberg, L.R., Serruya, M.D, Friehs, G.M, Mukand, J.A., Saleh, M, Caplan, A.H., Branner, A., Chen, D., Penn, R.D., and Donoghue, J.P. (2006)
Neuronal ensemble control of prosthetic devices by a human with tetraplegia.
Nature, 442(7099), 164-171 (13 July 2006)
PMID: 16838014 [PubMed - indexed for MEDLINE]

Abstract:
http://www.nature.com/nature/journal/v442/n7099/abs/nature04970.html

Nature issue:
http://www.nature.com/nature/journal/v442/n7099/index.html

Web Focus on Brain-Machine Interfaces:
http://www.nature.com/nature/focus/brain/index.html

Kübler, A., Mushahwar, V. K., Hochberg, L. R., and Donoghue, J. P. (2006)
BCI Meeting 2005--Workshop on Clinical Issues and Applications.
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2006 June, 14(2): 131-134.
PMID: 16792277 [PubMed - indexed for MEDLINE]
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Kim, S.-P., Wood, F., Fellows, M., Donoghue, J. P., Black, M. J. (2006)
Statistical analysis of the non-stationarity of neural population codes.
BioRob 2006, The first IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 295-299, Piza, Italy, February 2006.
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Wu, W., Gao, Y., Bienenstock, E., Donoghue, J. P., Black, M.J. (2005)
Bayesian population decoding of motor cortical activity using a Kalman filter
Neural Computation: 2005; 18(1):80-118.
PDF

Wood, F., Prabhat, Donoghue, J. P., Black, M. J. (2005)
Inferring attentional state and kinematics from motor cortical firing rates
Proc. IEEE Engineering in Medicine and Biology Society, pp 1544-1547, Sept. 2005.
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Shoham, S., Paninski, L.M., Fellows, M.R., Hatsopoulos, N.G., Donoghue, J.P., Normann, R.A. (2005).
Statistical Encoding Model for a Primary Motor Cortical Brain-Machine Interface.
IEEE Transactions on Biomedical Engineering, 52(7): 1312-1322.
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Zerris, V. A., Donoghue, J.P., Hochberg, L.R., and Friehs, G. (2005)
Braingate: Turning Thought into Action-First Experience with a Human Neuromotor Prosthesis: 885. [Abstract]
Neurosurgery 57(2):425, August 2005.

Suner, S., Fellows, M. R., Vargas-Irwin, C., Nakata, G. K., Donoghue, J. P. (2005)
Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex.
IEEE Transactions in Neural Systems and Rehabilitation Engineering, vol. 13, No. 4, 524-541.
PMID: 16425835 [PubMed - indexed for MEDLINE]
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Eden, U. T., Truccolo, W., Fellows, M. R., Donoghue, J. P., Brown, E. N. (2004)
Reconstruction of hand movement trajectories from a dynamic ensemble of spiking motor cortical neurons.
Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA.
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Song, Y. K., Patterson, W. R., Bull, C. W., Beals, J., Hwang, N., Deangelis, A. P., Lay, C., McKay, J. L., Nurmikko, A. V., Fellows, M. R., Simeral, J. D., Donoghue, J. P., Connors, B. W. (2004)
Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications.
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2005 June; 13(2): 220-226.
PMID: 16003903 [PubMed - indexed for MEDLINE]

Friehs, G. M., Zerris, V. A., Ojakangas, C. L., Fellows, M. R., Donoghue, J. P. (2004)
Brain-machine and brain-computer interfaces.
Stroke 2004 November; 35(11 Supplement 1); 2702-2705.
Epub 2004 Oct 14. Review.
PMID: 15486335 [PubMed - indexed for MEDLINE]

Patterson, W. R., Song, Y.-K., Bull, C. W., Ozden, I., Deangellis, A. P., Lay, C., McKay, J. L., Nurmikko, A. V., Donoghue, J. P., and Conners, B. W. (2004)
A Microelectrode/microelectronic hybrid device for brain implantable neuroprosthesis applications.
IEEE Transactions on Biomedical Engineering, vol. 51, No. 10, 1845-1853.
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Donoghue, J. P., Nurmikko, A., Friehs, G., and Black, M., J. (2004)
Chapter 63. Development of a neuromotor prosthesis for humans
in Advances in Clinical Neurophysiology,Supplements to Clinical Neurophysiology, Vol. 57, [Proceedings of the 27th International Congress of Clinical Neurophysiology, AAEM 50th Anniversary and the 57th Annual Meeting of the ACNS Joint Meeting, San Francisco, CA, USA, 15-20 September 2003] M. Hallett, L.H. Phillips II, D.L. Schomer, J.M. Massey, Eds., pp.588-602.
PMID: 16106661 [PubMed - indexed for MEDLINE]
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Wu, W., Shaikhouni, A., Donoghue, J. P., Black, M.J. (2004)
Closed loop neural control of cursor motion using a Kalman filter
Proc. IEEE Engineering in Medicine and Biology Society: 4126-4129, San Francisco, September 2004.
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Wood, F.D., Fellows, M., Donoghue, J. P., Black, M.J. (2004)
Automatic spike sorting for neural decoding
Proc. IEEE Engineering in Medicine and Biology Society: 4009-4012, San Francisco, September 2004.
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Fofonoff, T.A.; Martel, S.M.; Hatsopoulos, N.G.; Donoghue, J.P.; Hunter, I.W. (2004)
Microelectrode array fabrication by electrical discharge machining and chemical etching.
IEEE Transactions on Biomedical Engineering 51 (6): 890-889 June 2004.
PMID: 15188855 [PubMed - indexed for MEDLINE]
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Wood, F., Black, M. J., Vargas-Irwin, C., Fellows, M., Donoghue, J. P. (2004)
On the variability of manual spike sorting.
IEEE Transactions on Biomedical Engineering 51 (6): 912-918 June 2004.
PMID: 15188858 [PubMed - indexed for MEDLINE]
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Wu, W., Black, M.J., Mumford, D., Gao, Y., Bienenstock, E., Donoghue, J. P. (2004)
Modeling and decoding motor cortical activity using a switching Kalman filter
IEEE Transactions on Biomedical Engineering 51 (6): 933-942 June 2004.
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Serruya MD, Donoghue JP. (2003)
Chapter III: Design Principles of a Neuromotor Prosthetic Device
in Neuroprosthetics: Theory and Practice, ed. Kenneth W. Horch, Gurpreet S. Dhillon. Imperial College Press. pages 1158-1196.
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Wu, W., Black, M. J., Mumford, D., Gao, Y., Bienenstock, E., Donoghue, J. P. (2003)
A switching Kalman filter model for the motor cortical coding of hand motion.
Proc. IEEE EMBS, pp. 2083-2086, Cancun, Sept. 2003.
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Black, M.J., Serruya, M., Bienenstock, E., Gao, Y., Wu, W., and Donoghue, J.P. (2003)
Connecting brains with machines: the neural control of 2D cursor movement.
Proceedings of the First International IEEE EMBS Conference on Neural Engineering,, pp. 580-583, 19-22 March 2003, Capri Island, Italy.
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Serruya, M., Hatsopoulos, N. Fellows, M. Paninski, L, and Donoghue, J. (2003)
Robustness of neuroprosthetic decoding algorithms.
Biological Cybernetics 88 (3): 219-228 March 2003.
Springerlink to PDF The original publication is available at http://link.springer-ny.com.

Wu, W., Black, M. J., Gao, Y., Bienenstock, E., Serruya, M., Shaikhouni, A., Donoghue, J. P. (2002)
Neural decoding of cursor motion using a Kalman filter
Neural Information Processing Systems, NIPS, Vancouver, BC, Dec. 2002.
PDF

Wu, W., Black, M. J., Gao, Y., Bienenstock, E., Serruya, M., and Donoghue, J. P. (2002)
Inferring hand motion from multi-cell recordings in motor cortex using a Kalman filter
SAB'02-Workshop on Motor Control in Humans and Robots: On the Interplay of Real Brains and Artificial Devices, August 10, 2002, Edinburgh, Scotland (UK), pp. 66-73.
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Donoghue, J.P. (2002)
Connecting cortex to machines: recent advances in brain interfaces.
Nature Neuroscience Supplement, November 2002. 5:1085-8.
PMID: 12403992 [PubMed - indexed for MEDLINE]
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Fofonoff, T., Martel, S., Wiseman, C., Dyer, R., Hunter, I., Hatsopoulos, N., and Donoghue, J. (2002)
A highly flexible manufacturing technique for microelectrode array fabrication.
[Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] Proceedings of the Second Joint EMBS/BMES Conference, 23-26 October 2002. 3: 2107-8.
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Serruya, M.D., Hatsopoulos, N.G., Paninski, L., Fellows, M.R., and Donoghue, J.P. (2002)
Instant neural control of a movement signal
Nature 416:141-2.
PMID: 11894084 [PubMed - indexed for MEDLINE]
PDF

Burgert, J., Malasek, J., Martel, S., Wiseman, C., Dyer, R., Hunter, I., Hatsopoulos, N., Donoghue, J. (2001).
Embedded Electronics for a 64-Channel Wireless Brain Implant.
SPIE: Microbiotics and Microassembly

Martel, S., Hatsopoulos, N., Donoghue, J., Hunter, I., Burgert, J., Malasek, J., Wiseman, C., Dyer, R. (2001).
Development of a Wireless Brain Implant: the Telemetric Electrode Array System (TEAS) Project.
23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Fofonoff, T., Wiseman, C., Dyer, R., Malasek, J., Burgert, J., Martel, S., Hunter, I., Hatsopoulos, N., Donoghue, J. (2002).
Mechanical Assembly of a Microelectrode Array for Use in a Wireless Intracortical Recording Device.
2nd Annual International IEEE-EMBS Special Topic Conference on Mircotechnologies in Medicine and Biology, p. 269-272.

Neural Representation/Coding Motor Control

Wu, W., Gao, Y., Bienenstock, E., Donoghue, J. P., Black, M.J. (2006)
Bayesian population decoding of motor cortical activity using a Kalman filter
Neural Computation: 2006 January; 18(1):80-118.
PMID: 16354382 [PubMed - indexed for MEDLINE]
PDF

Truccolo, W., Eden, U. T., Fellows, M. R., Donoghue, J. P., Brown, E. N. (2005)
A point process framework for relating neural spiking activity to spiking history, neural ensemble and extrinsic covariate effects.
J. Neurophysiology 93(2): 1074-1089. PMID: 15356183 [PubMed - indexed for MEDLINE]

Paninski, L., Shoham, S., Fellows, M., Hatsopoulos, N., & Donoghue, J. (2004).
Superlinear population encoding of dynamic hand trajectory in primary motor cortex.
Journal of Neuroscience, 24(39): 8551-8561.
PMID: 15456829 [PubMed - indexed for MEDLINE]
JNS PDF

Paninski, L., Fellows, M.R., Hatsopoulos, N.G., and Donoghue, J.P. (2004)
Spatiotemporal tuning of motor cortical neurons for hand position and velocity.
Journal of Neurophysiology 91(1): 515-32.
PMID: 13679402 [PubMed - indexed for MEDLINE]

Wu, W., Black, M. J., Mumford, D., Gao, Y., Bienenstock, E., Donoghue, J. P. (2003)
A switching Kalman filter model for the motor cortical coding of hand motion.
to appear: Proc. IEEE EMBS, Cancun, Sept. 2003.
PDF

Gao, Y., Black, M.J., Bienenstock, E., Wu, W., and Donoghue, J.P. (2003)
A quantitative comparison of linear and non-linear models of motor cortical activity for the encoding and decoding of arm motions.
1st International IEEE/EMBS Conference on Neural Engineering, Capri, Italy, March 20-22, 2003, 189-192.
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Hatsopoulos, N.G., Paninski, L., Donoghue, J.P. (2003)
Sequential movement representations based on correlated neuronal activity.
Experimental Brain Research 14(4)9:478-86 Apr 2003.
PMID: 12677328 [PubMed - indexed for MEDLINE]
Springerlink to PDF The original publication is available at http://link.springer-ny.com.

Sanes, J.N. and Truccolo, W. (2003)
Motor "binding": Do functional assemblies in primary motor cortex have a role?
Neuron 38(1): 3-5 April 10, 2003.

Shoham, S., Fellows, M.R., and Normann, R.A. (2003)
Robust, automatic spike sorting using mixtures of multivariate t-distributions.
Journal of Neuroscience Methods (to appear August 15, 2003)
href="pubs/Shoham2003preprint.pdf">preprint PDF

Acuna, B.D., Eliassen, J.C., Donoghue, J.P., and Sanes, J.N. (2002)
Frontal and parietal lobe activation during transitive interference in humans.
Cerebral Cortex, 12:1312-21.
PMID: 12427681 [PubMed - indexed for MEDLINE]
PDF
The original document is available at Cerebral Cortex journal website.

Acuna, B.D., Sanes, J.N., and Donoghue, J.P. (2002)
Cognitive mechanisms of transitive inference.
Experimental Brain Research. 146(1):1-10.
PMID: 12192572 [PubMed - indexed for MEDLINE]
Springerlink to PDF The original publication is available at http://link.springer-ny.com.

Gao, Y., Black, M.J., Bienenstock, E., Shoham, S., and Donoghue, J.P. (2002)
Probabilistic interference of hand motion from neural activity in motor cortex.
[15th annual IEEE Conference on Advances in Neural Information Processing Systems (NIPS), British Colombia, Canada, 3-8 December 2001], Advances in Neural Information Processing Systems 14: Proceedings of the 2002 Conference. Eds. T.G. Dietterich, S. Becker and Z. Ghahramani, 14(1):221-228, The MIT Press, 2002.
PDF (postscript) (abstract)

Wu, W., Black, M. J., Gao, Y., Bienenstock, E., Serruya, M., Shaikhouni, A., Donoghue, J. P. (2003)
Neural decoding of cursor motion using a Kalman filter
Advances in Neural Information Processing Systems 15, S. Becker, S. Thrun and K. Obermayer (Eds.), MIT Press, pp. 117-124, 2003. [Proceedings of NIPS, Vancouver, BC, Dec. 2002].
PDF

Hatsopoulos, N.G., Harrison, M.T., and Donoghue, J.P. (2001)
Representations based on neuronal interactions in motor cortex
Progress in Brain Research 130:233-44.
PMID: 11480278 [PubMed - indexed for MEDLINE]

Oram, M.W., Hatsopoulos, N.G., Richmond, B.J., and Donoghue, J.P. (2001)
Excess synchrony in motor cortical neurons provides redundant direction information with that from coarse temporal measures
Journal of Neurophysiology 86(4):1700-16.
PMID: 11600633 [PubMed - indexed for MEDLINE]

Baker, J.T., Donoghue, J.P., and Sanes, J.N. (1999)
Gaze direction modulates finger movement activation patterns in human cerebral cortex.
Journal of Neuroscience. 19(22):10044-52.
PMID: 10559412 [PubMed - indexed for MEDLINE]
JNS PDF

Hess, G., and Donoghue, J.P. (1999)
Facilitation of long-term potentiation in layer II/III horizontal connections of rat motor cortex following layer I simulation: route of effect and cholinergic contributions.
Experimental Brain Research. 127(3):279-90.
Springerlink to PDF The original publication is available at http://link.springer-ny.com

Maynard, E.M., Hatsopoulos, N.G., Ojakangas, C.L., Acuna, B.D., Sanes, J.N., Normann, R.A., and Donoghue, J.P. (1999)
Neuronal interactions improve cortical population coding of movement direction
Journal of Neuroscience. 19(18):8083-93.
PMID: 10479708 [PubMed - indexed for MEDLINE]
JNS PDF

Donoghue, J.P., Sanes, J.N., Hatsopoulos, N.G., and Gaal, G. (1998)
Neural discharge and local field potential oscillations in primate motor cortex during voluntary movements
Journal of Neurophysiology. 79:159-73.
PMID: 9425187 [PubMed - indexed for MEDLINE]

Hatsopoulos, N.G., Ojakangas, C.L., Maynard, E.M. and Donoghue, J.P. (1998)
Detection and identification of ensemble codes in motor cortex
In: Neuronal Ensembles: Strategies for recording and decoding, J. Davis and H. Eichenbaum, eds. New York: Wiley and Sons.

Hatsopoulos, N.G., Ojakangas, C.L., Paninski, L., and Donoghue, J.P. (1998)
Information about movement direction obtained from synchronous activity of motor cortical neurons
Proceedings of the National Academy of Sciences of the United States of America 95(26):15706-11.
PMID: 9861034 [PubMed - indexed for MEDLINE]
PNAS PDF

Sanes, J.N., Donoghue, J.P., Thangaray, V., Endelman, R.R., and Warach, S. (1995)
Shared neural substrates controlling hand movements in human motor cortex.
Science 268 (5218): 1775-1777 June 23, 1995.
PMID: 7792606 [PubMed - indexed for MEDLINE]

Donoghue, J.P. and Sanes, J.N. (1994)
Motor areas of the cerebral cortex
J. Clin. Neurophysiol. 11: 382-96.
PMID: 7962487 [PubMed - indexed for MEDLINE]

Hess, G., Jacobs, K.M., and Donoghue, J.P. (1994)
N-methyl-d-aspartate receptor-mediated component of field potentials-evoked in horizontal pathways of rat motor cortex.
Neuroscience 61 (2): 225-235 July 1994.
PMID: 7969904 [PubMed - indexed for MEDLINE]

Jacobs, K.M., Neve, R.L., and Donoghue, J.P. (1993)
Neocortex and hippocampus contain distinct distributions of calcium-calmodulin protein kinase-II and GAP43 messenger-RNA.
Journal of Comparative Neurology 336 (1): 151-160 October 1, 1993.
PMID: 8254111 [PubMed - indexed for MEDLINE]

Sanes, J.N. and Donoghue, J.P. (1993)
Oscillations in local field potentials of the primate motor cortex during voluntary movement
Proceedings of the National Academy of Sciences of the United States of America 90(10): 4470-4.
PMID: 8506287 [PubMed - indexed for MEDLINE]
PNAS PDF

Donoghue, J.P., Leibovic, S., and Sanes, J.N. (1992)
Organization of the forelimb area in squirrel-monkey motor cortex - representation of digit, wrist, and elbow muscles.
Experimental Brain Research 89 (1): 1-19 April 1992.
PMID: 1601087 [PubMed - indexed for MEDLINE]

Sanes, J.N., Wang, J., and Donoghue, J.P. (1992)
Immediate and delayed changes of rat motor cortical output representation with new forelimb configurations.
Cerebral Cortex 1992 Mar.-Apr.: 2(2): 141-52.
PMID: 1633412 [PubMed - indexed for MEDLINE]

Sahin, M. Bowen, W.D., and Donoghue, J.P. (1992)
Location of nicotinic and nuscarinic cholinergic and mu-opiate receptors in rat cerebral neocortex - evidence from thalamic and cortical-lesions.
Brain Research 579 (1): 135-147 May 1, 1992.
PMID: 1320443 [PubMed - indexed for MEDLINE]

Jacobs, K.M., and Donoghue, J.P. (1991)
Reshaping the cortical motor map by unmasking latent intracortical connections.
Science 251 (4996): 944-947 February 22, 1991.
PMID: 2000496 [PubMed - indexed for MEDLINE]
DOI: 10.1126/science.2000496

Motor Plasticity

Rioult-Pedotti, M.S., Friedman, D., and Donoghue, J.P. (2000)
Learning-induced LTP in neocortex
Science 2000 October 20, 290(5491):533-6 (in Reports).
PMID: 11039938 [PubMed - indexed for MEDLINE]
PDF The official online version is available at www.scienceonline.org link

Sanes, J.N. and Donoghue, J.P. (2000)
Plasticity and primary motor cortex
Annual Review of Neuroscience. 23:393-415.
PMID: 10845069 [PubMed - indexed for MEDLINE]
PDF The original publication is available at Annual Review web page
Annual Review web page

Hess, G., and Donoghue, J.P. (1999)
Facilitation of long-term potentiation in layer II/III horizontal connections of rat motor cortex following layer I simulation: route of effect and cholinergic contributions.
Experimental Brain Research. 127(3):279-90.
PMID: 10452215 [PubMed - indexed for MEDLINE]
Springerlink to PDF The original publication is available at http://link.springer-ny.com

Hess, G. and Donoghue, J.P. (1998)
Synaptic modifications of horizontal connections in rat motor cortex induced by conjoint activation of layer I and II/III.
European Journal of Neuroscience 10: 901 Supplement 10 1998. (meeting abstract)

Rioult-Pedotti, M.S., Friedman, D., and J.P. Donoghue (1998)
Strengthening of horizontal cortical connections following skill learning
Nature Neuroscience 1(3):230-234.
PMID: 10195148 [PubMed - indexed for MEDLINE]
PDF

Donoghue, J. P. (1997)
Commentary: Limits of reorganization in cortical circuits.
Cerebral Cortex 7(2): 97-99 March 1997.
PMID: 9087818 [PubMed - indexed for MEDLINE]
PDF
The original publication is available at Cerebral Cortex journal website.

Sanes, J.N. and Donoghue, J.P. (1997)
Dynamic motor cortical organization.
Neuroscientist 3(3): 158-165 May 1997.

Sanes, J.N. and Donoghue, J.P. (1997)
Static and Dynamic Organization of Motor Cortex,
Advances in Neurology, Brain Plasticity. Eds. H.-J. Freund, B.A. Sabel and O.W. Witte. Philadelphia: Lippincott-Raven. 73: 277-96.
PMID: 8959220 [PubMed - indexed for MEDLINE]

Donoghue, J.P., Hess, G. and Sanes, J.N. (1996)
Substrates and mechanisms for learning in motor cortex
In Acquisition of Motor Behavior in Vertebrates. Eds. J. Bloedel, T. Ebner and S. P. Wise. MIT Press.

Hess, G., Aizenman, C.D. and Donoghue, J.P. (1996)
Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex
Journal of Neurophysiology 75:1765-78.
PMID: 8734579 [PubMed - indexed for MEDLINE]

Hess. G. and Donoghue, J.P. (1996)
Long-term depression of horizontal connections in rat motor cortex
European Journal of Neuroscience 8 (4): 658-665 April 1996.
PMID: 9081617 [PubMed - indexed for MEDLINE]
PDF

Hess, G. and Donoghue, J.P. (1996)
Long-term potentiation and long-term depression of horizontal connections in rat motor cortex
Acta Neurobiologiae Experimentalis 56 (1): 397-405 1996.
PMID: 8787200 [PubMed - indexed for MEDLINE]

Castroalamancos, M.A., Donoghue, J.P., and Connors, B.W. (1995)
Different forms of synaptic plasticity in somatosensory and motor areas of the neocortex.
Journal of Neuroscience 4(7): 5324-5333 Part 2 July 1995.
PMID: 7623155 [PubMed - indexed for MEDLINE]
JNS PDF

Donoghue, J.P. (1995)
Plasticity of adult sensorimotor representations.
Current Opinion in Neurobiology 5(6): 749-754 December 1995.
PMID: 8805413 [PubMed - indexed for MEDLINE]
PDF

Hess, G. and Donoghue, J.P. (1994)
Long-term potentiation of horizontal connections provides a mechanism to reorganize cortical maps
Journal of Neurophysiology. 71: 2543-7.
PMID: 7931533 [PubMed - indexed for MEDLINE]
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Sanes, J.N. and Donoghue, J.P. (1992)
Organization and adaptability of muscle representations in primary motor cortex.
Experimental Brain Research Supplement 22: 103-27.

Jacobs, K.M., and Donoghue, J.P. (1991)
Reshaping the cortical motor map by unmasking latent intracortical connections.
Science 251 (4996): 944-947 February 22, 1991.

Donoghue, J.P., Suner, S., and Sanes, J.N. (1990)
Dynamic organization of primary motor cortex output to target muscles in adult rats .2. rapid reorganization following motor-nerve lesions.
Experimental Brain Research 79 (3): 492-503 1990.
DOI: 10.1007/BF00229319

Sanes, J.N, Suner, S., and Donoghue, J.P. (1990)
Dynamic organization of primary motor cortex outout to target muscles in adult rats .1. long-term patterns of reorganization following motor or mixed peripheral-nerve lesions.
Experimental Brain Research: 79(3):479-91.
PMID: 2340868 [PubMed - indexed for MEDLINE]
DOI: 10.1007/BF00229318

Donoghue, J.P. and Sanes, J.N. (1988)
Organization of adult motor cortex representation paterns following neonatal forelimb nerve injury in rats.
Journal of Neuroscience 8 (9): 3221-3232 September 1988.
JNS PDF

Sanes, J.N., Suner, S., Lando, J.F., and Donoghue, J.P. (1988)
Rapid reorganization of adult-rat cortex somatic representation patterns after motor-nerve injury.
Proceedings of the National Academy of Sciences of the United States of America 85 (6): 2003-2007 March 1988.

Donoghue, J.P. and Carroll, K.L. (1987)
Cholinergic modulation of sensory responses in rat primary somatic sensory cortex.
Brain Research 1987 Apr 7;408(1-2):367-71.
PMID: 3594226 [PubMed - indexed for MEDLINE]

Donoghue, J.P. and Sanes, J.N. (1987)
Peripheral nerve injury in developing rats reorganizes representation pattern in motor cortex.
Proceedings of the National Academy of Sciences of the United States of America 1987 Feb;84(4):1123-6.
PMID: 3469649 [PubMed - indexed for MEDLINE]

Donoghue, J.P. (1987)
Cholinergic modulation of sensory responses in cerebral cortex.
NIDA Research Monographs 1987;78:169-88. Review.
PMID: 3123987 [PubMed - indexed for MEDLINE]

Donoghue J.P. and Herkenham, M. (1986)
Neostriatal projections from individual cortical fields conform to histochemically distinct striatal compartments in the rat.
Brain Research 1986 Feb 19;365(2):397-403.
PMID: 3004664 [PubMed - indexed for MEDLINE]

Donoghue J.P., Wenthold R.J.,and Altschuler R.A. (1985)
Localization of glutaminase-like and aspartate aminotransferase-like immunoreactivity in neurons of cerebral neocortex.
Journal of Neuroscience 1985 Oct;5(10):2597-608.
PMID: 4045547 [PubMed - indexed for MEDLINE]

Donoghue, J.P. (1985)
Contrasting properties of neurons in two parts of the primary motor cortex of the awake rat.
Brain Research 1985 Apr 29;333(1):173-7.
PMID: 3995285 [PubMed - indexed for MEDLINE]

Donoghue J.P. and Parham C.(1983)
Afferent connections of the lateral agranular field of the rat motor cortex.
J Comp Neurol. 1983 Jul 10;217(4):390-404.
PMID: 6886060 [PubMed - indexed for MEDLINE]

Donoghue, J.P. and Wise, S.P. (1982)
The motor cortex of the rat: cytoarchitecture and microstimulation mapping.
J Comp Neurol. 1982 Nov 20;212(1):76-88.
PMID: 6294151 [PubMed - indexed for MEDLINE]

Deniau JM, Kitai ST, Donoghue JP, Grofova I. (1982)
Neuronal interactions in the substantia nigra pars reticulata through axon collaterals of the projection neurons. An electrophysiological and morphological study.
Experimental Brain Research 1982;47(1):105-13.
PMID: 6288427 [PubMed - indexed for MEDLINE]

Donoghue J.P. and Kitai S.T. (1981)
A collateral pathway to the neostriatum from corticofugal neurons of the rat sensory-motor cortex: an intracellular HRP study.
J Comp Neurol. 1981 Sep 1;201(1):1-13.
PMID: 7276247 [PubMed - indexed for MEDLINE]

Donoghue J.P. and Ebner F.F. (1981)
The laminar distribution and ultrastructure of fibers projecting from three thalamic nuclei to the somatic sensory-motor cortex of the opossum.
J Comp Neurol. 1981 May 20;198(3):389-420.
PMID: 7240451 [PubMed - indexed for MEDLINE]

Donoghue J.P. and Ebner F.F. (1981)
The organization of thalamic projections to the parietal cortex of the Virginia opossum.
J Comp Neurol. 1981 May 20;198(3):365-88.
PMID: 7240450 [PubMed - indexed for MEDLINE]

Foster R.E., Donoghue J.P. and Ebner F.F. (1981)
Laminar organization of efferent cells in the parietal cortex of the Virginia opossum.
Experimental Brain Research 1981;43(3-4):330-6.
PMID: 7262228 [PubMed - indexed for MEDLINE]

Donoghue J.P. and Wells J. (1977)
Synaptic rearrangement in the ventrobasal complex of the mouse following partial cortical deafferentation.
Brain Research 1977 Apr 15;125(2):351-5.
PMID: 851881 [PubMed - indexed for MEDLINE]