Donoghue Lab, Neuroscience Dept., Brown U.

Donoghue Lab, Neuroscience Department, Brown University

“…in the central nervous system the events in each unit are not so important. We are more concerned with the interactions of large numbers, and our problem is to find the way in which the interactions can take place.”
“The history of electrophysiology has been decided by the history of electrical recording instruments.“

As A. V. Hill (The Ethical Dilemma of Science, 1960) has said, Adrian, by thus showing that the afferent effect in a given neurone depends on the pattern in time of the impulses travelling in it, has provided a new quantitative basis of nervous behaviour.

Lord E.D. Adrian

Nobel Prize in Medicine, 1932 for discoveries regarding the function of neurons. First to record single action potentials; first study of spike based coding.

Updates

03 Feb 2010: People updated.

25 Jan 2010: Publications updated.

19 Jan 2010: Neurorehab Postdoc

21 Sept 2009: Braingate2 Postdoctoral Fellowships

News

7 Nov 2008: Science
News Focus
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31 Oct 2008: CBS
60 Minutes
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Obstacles
Brain Power

13 July 2006: Nature
442(7099)
Abstract
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For information about the BrainGate human pilot clinical trial see: http://www.braingate2.org/clinicalTrials.org.

Neural Codes

Our lab investigates how the brain turns thought into action... (more)

Neural Prosthetics (Brain Machine Interfaces)

We are also applying our knowledge of neural codes for movement to build prosthetic devices that provide an interface between the brain and the external world for individuals with paralysis... (more)

Recent Publications

Dushanova, J., Donoghue, J. (2010)
Neurons in primary motor cortex engaged during action observation
European Journal of Neuroscience vol. 31, issue 2, pp. 386-398.
doi: 10.1111/j.1460-9568.2009.0767.x
EJN link
Truccolo, W. (2010)
Stochastic models for multivariate neural point processes: collective dynamics and neural decoding.
in Analysis of Parallel Spike Trains (eds. Grün, S. & Rotter, S.), Springer, New York, 2010.
publisher's description
Truccolo, W., Hochberg, L.R., Donoghue, J.P. (2009)
Collective Dynamics in Human and Monkey Sensorimotor Cortex: Predicting Single Neuron Spikes.
Nature Neuroscience 6 Dec 2009, doi:10.1038/nn.2455
(Epub ahead of print) .
Song, Y.-K.; Borton, D.A.; Park, S.; Patterson, W.R.; Bull, C.W.; Laiwalla, F.; Mislow, J.; Simeral, J.D.; Donoghue, J.P.; Nurmikko, A.V. (2009)
Active Microelectronic Neurosensor Arrays for Implantable Brain Communication Interfaces
IEEE Transactions on Neural Systems and Rehabilitation Engineering vol. 17, issue 4, August 2009 Pages 339-345. Epub 2009 Jun 5
doi: 10.1109/TNSRE.2009.2024310
PMID: 19502132 [PubMed - indexed for MEDLINE]
PDF
Hatsopoulos NG, Donoghue JP. (2009)
The Science of Neural Interface Systems. Annu Rev Neurosci. 2009 Mar 24.
[Epub ahead of print]
John P. Donoghue (2008)
Bridging the brain to the world: a perspective on neural interface systems.
Neuron 60, November 6, 2008, pp. 511-521, 2008.
summary
Sung-Phil Kim, John Simeral, Leigh Hochberg, John P Donoghue and Michael J Black (2008).
Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia
J. Neural Eng., vol. 5, pp. 455-476, 2008.
pdf preprint
PDF from publisher
Philip BA, Wu Y, Donoghue JP, Sanes JN. (2008)
Performance differences in visually and internally guided continuous manual tracking movements
Experimental Brain Research, 2008 July 23 [Epub ahead of print].
PMID: 18648785 [PubMed - as supplied by publisher]
SpringerLink
Truccolo, W., Friehs, G.M., Donoghue, J.P., Hochberg, L.R. (2008).
Primary Motor Cortex Tuning to Intended Movement Kinematics in Humans with Tetraplegia.
Journal of Neuroscience January 30, 2008, 28(5):1163-1178.
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